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Remember that GLP-1 injectable medications can be administered regardless of meal timing, while oral semaglutide (Rybelsus) must be taken on an empty stomach with a small sip of water (120ml) at least 30 minutes before eating, drinking or taking other oral medicines

Exenatide (shown on the right, PDB 7LLL), which was the first GLP-1 receptor agonist approved by the FDA, shares just over 50% sequence identity with GLP-1, but has a similar structure and is able to activate the GLP-1 receptor, while avoiding rapid proteolytic degradation

Structure and function of haemoglobins

This often results in an average weight loss of about 15% when paired with lifestyle changes